Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12015801 | 0.83 | NOTUM (0.41) | LMNATRPA1PTGS1CACNA1CHIF1A | |
| SCHEMBL14200344 | 0.77 | LMNA (0.41) | LMNATRPA1PTGS1CACNA1CHIF1A | |
| SCHEMBL2098921 | 0.76 | CYP1A2 (0.31) | CYP2D6CYP1A2ALDH1A1 | |
| SCHEMBL16259646 | 0.74 | CYP2D6 (0.41) | CYP2D6CYP1A2TRPA1PTGS1CACNA1C | |
| SCHEMBL24848636 | 0.74 | CYP1A2 (0.41) | CYP2D6CYP1A2LMNAALDH1A1GAA | |
| SCHEMBL20909917 | 0.74 | ALDH1A1 (0.41) | CYP1A2LMNAPTGS1HIF1AALDH1A1 | |
| SCHEMBL22790526 | 0.74 | LMNA (0.54) | CYP2D6CYP1A2LMNATRPA1PTGS1 | |
| SCHEMBL12248233 | 0.74 | LMNA (0.39) | LMNATRPA1PTGS1CACNA1CHIF1A | |
| SCHEMBL14328458 | 0.74 | LMNA (0.48) | LMNATRPA1PTGS1CACNA1CHIF1A | |
| SCHEMBL26519517 | 0.73 | CYP1A2 (0.36) | CYP2D6CYP1A2LMNATRPA1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190106427-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2019-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106427-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | WEE1, WEE2, NME1 | CYP2D6 2748/4885CYP1A2 3179/4885LMNA 3549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.