Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15658784 | 0.90 | LMNA (0.56) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL17630265 | 0.90 | LMNA (0.66) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL15658785 | 0.90 | LMNA (0.56) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL574625 | 0.89 | MAPT (0.49) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL574624 | 0.89 | MAPT (0.49) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL6808636 | 0.85 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL29803356 | 0.85 | ALDH1A1 (0.67) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL4509252 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL4509247 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL29556577 | 0.84 | ALDH1A1 (0.64) | ALDH1A1MAPTLMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3752491-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3694509-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Nuvation Bio Inc. (US) | 2020-08-19 | — | — | EP | disclosed |
| WO-2019161224-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | GiraFpharma LLC (US) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019074981-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GiraFpharma LLC (US) | 2019-04-18 | — | — | WO | disclosed |