Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21941201 | 0.92 | PDK2 (0.33) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL19631375 | 0.77 | SCN9A (0.36) | KDM4ETDP1 | |
| SCHEMBL16946700 | 0.77 | PDK2 (0.43) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL16947094 | 0.71 | AAK1 (0.37) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL18353076 | 0.71 | AAK1 (0.37) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL21601459 | 0.71 | PDK2 (0.47) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL16947088 | 0.70 | RBP4 (0.39) | RBP4 | |
| SCHEMBL24552685 | 0.69 | PKM (0.49) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL21076921 | 0.69 | PDK2 (0.45) | RBP4PDK2HTR2CSLC6A4HTR2A | |
| SCHEMBL21601517 | 0.69 | PDK2 (0.45) | RBP4PDK2HTR2CSLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097107-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TP THERAPEUTICS INC (US) | 2019-04-17 | — | — | EP | disclosed |