Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087120 | 0.99 | TP53 (0.40) | TP53SMN1; SMN2HPGDMRGPRX4HRH3 | |
| SCHEMBL2088703 | 0.87 | NPC1 (0.38) | TP53SMN1; SMN2HPGDHRH3ALDH1A1 | |
| SCHEMBL2087637 | 0.85 | MRGPRX4 (0.36) | TP53SMN1; SMN2HPGDMRGPRX4HRH3 | |
| SCHEMBL2938443 | 0.80 | HPGD (0.41) | TP53SMN1; SMN2HPGDHRH3ALDH1A1 | |
| SCHEMBL27841694 | 0.76 | KMT2A (0.47) | TP53ALDH1A1TSHRKMT2AKDM4E | |
| SCHEMBL15226369 | 0.75 | KMT2A (0.39) | SMN1; SMN2HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL10686849 | 0.75 | KMT2A (0.39) | SMN1; SMN2HPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL28542992 | 0.74 | ALDH1A1 (0.43) | TP53SMN1; SMN2HPGDALDH1A1RAB9A | |
| SCHEMBL27844750 | 0.73 | POLB (0.43) | SMN1; SMN2HPGDALDH1A1RAB9AMAPT | |
| SCHEMBL30159879 | 0.71 | ALDH1A1 (0.58) | SMN1; SMN2HPGDMRGPRX4ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863450-B2 | Compounds comprising an oxazoline or thiazoline moiety, processes for making them, and their uses | UCB PHARMA, S.A. (BE) | 2011-01-04 | — | — | US | disclosed |