⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21450443 | 0.85 | EPHX2 (0.30) | — | |
| SCHEMBL24753932 | 0.82 | LMNA (0.31) | — | |
| SCHEMBL23492999 | 0.81 | EPHX2 (0.40) | — | |
| SCHEMBL24936541 | 0.80 | — | — | |
| SCHEMBL25952776 | 0.79 | — | — | |
| SCHEMBL23964067 | 0.77 | — | — | |
| SCHEMBL21766915 | 0.77 | — | — | |
| SCHEMBL20386911 | 0.77 | CA12 (0.34) | — | |
| SCHEMBL27402642 | 0.76 | FAAH (0.32) | — | |
| SCHEMBL28707384 | 0.74 | TDP1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4389752-A1 | CAMPTOTHECIN DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Simcere Zaiming Pharmaceutical Co., Ltd. (CN) | 2024-06-26 | — | — | EP | disclosed |
| US-20230256109-A1 | Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy | TAMBO, INC. | 2023-08-17 | — | — | US | disclosed |
| US-20230241241-A1 | CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-08-03 | — | — | US | disclosed |
| WO-2023078464-A1 | EPSILON-POLY-L-LYSINE-BASED DRUG CONJUGATE, INTERMEDIATE THEREOF, AND APPLICATION THEREOF | 上海弼领生物技术有限公司 | 2023-05-11 | — | — | WO | disclosed |
| US-20220193069-A1 | CAMPTOTHECIN PEPTIDE CONJUGATES | SEAGEN INC (US) | 2022-06-23 | — | — | US | disclosed |
| WO-2021225892-A1 | ANTIBODY-DRUG CONJUGATES (ADCS) COMPRISING AN ANTI-TROP-2 ANTIBODY, COMPOSITIONS COMPRISING SUCH ADCS, AS WELL AS METHODS OF MAKING AND USING THE SAME | LEVENA (SUZHOU) BIOPHARMA CO., LTD. (CN) | 2021-11-11 | — | — | WO | disclosed |
| WO-2021113643-A2 | METHODS AND COMPOSITIONS FOR SYNTHESIS OF THERAPEUTIC NANOPARTICLES | Dantari, Inc. (US) | 2021-06-10 | — | — | WO | disclosed |
| EP-3808751-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Marine Biomedical Research Institute Of Qingdao Co., Ltd. (CN) | 2021-04-21 | — | — | EP | disclosed |
| US-10828373-B2 | Bioorthogonal compositions | TAMBO, INC. (US) | 2020-11-10 | — | — | US | disclosed |
| US-10716801-B2 | Silanol based therapeutic payloads | BLINKBIO, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20200190101-A1 | Composition Containing Novel Glutamic Acid Derivative And Block Copolymer, And Use Thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2020-06-18 | — | — | US | disclosed |
| US-20190343828-A1 | CAMPTOTHECIN PEPTIDE CONJUGATES | SEATTLE GENETICS, INC. (US) | 2019-11-14 | — | — | US | disclosed |
| US-20190183913-A1 | Silanol Based Therapeutic Payloads | BLINKBIO INC (US) | 2019-06-20 | — | — | US | disclosed |
| US-20190111142-A1 | Silanol Based Therapeutic Payloads | BLINKBIO, INC. (US) | 2019-04-18 | — | — | US | disclosed |