Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20891206 | 0.94 | ADRA1D (0.42) | PLAUJAK2FLT3ADRA1DADRA1A | |
| SCHEMBL1708015 | 0.87 | ADRA1D (0.51) | PLAUADRA1DADRA1AADRA1BADRA2A | |
| SCHEMBL20884109 | 0.82 | PLAU (0.43) | PLAUJAK2FLT3ADRA1DADRA1A | |
| SCHEMBL6961088 | 0.81 | PLAU (0.47) | PLAUJAK2FLT3ADRA1DADRA1A | |
| SCHEMBL10673802 | 0.81 | DRD1 (0.53) | PLAUADRA2AADRA2BADRA2CDRD1 | |
| SCHEMBL20883596 | 0.81 | JAK2 (0.43) | PLAUJAK2FLT3ADRA1DADRA1A | |
| SCHEMBL6369707 | 0.80 | HRH3 (0.51) | MEN1KMT2AGAAATMPOLB | |
| SCHEMBL3957205 | 0.78 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL13255041 | 0.78 | DRD2 (0.54) | MEN1KMT2AGAAATMPOLB | |
| Bromide SCHEMBL6521671 | 0.77 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022236253-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2019074979-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GIRAFPHARMA, LLC (US) | 2019-04-18 | — | — | WO | disclosed |