Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | TGM1 | P22735 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20899330 | 0.83 | AR (0.31) | TP53 | |
| SCHEMBL18645249 | 0.81 | LRRK2 (0.41) | ALDH1A1LMNAKDM4EHSD17B10HTT | |
| SCHEMBL20910330 | 0.77 | LMNA (0.36) | ALDH1A1LMNAKDM4EHSD17B10HTT | |
| SCHEMBL12837968 | 0.75 | LMNA (0.44) | ALDH1A1LMNAKDM4EHSD17B10NOS1 | |
| SCHEMBL15601835 | 0.75 | EGLN1 (0.37) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL13390165 | 0.75 | HCRTR1 (0.38) | ALDH1A1LMNAKDM4EHSD17B10HTT | |
| SCHEMBL12837966 | 0.74 | NOS1 (0.44) | ALDH1A1NOS1TGM2TGM1 | |
| SCHEMBL15601838 | 0.74 | LRRK2 (0.34) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15601827 | 0.73 | GCGR (0.38) | ALDH1A1LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL24354406 | 0.70 | KDM4E (0.34) | ALDH1A1LMNAKDM4EHSD17B10NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019074962-A1 | PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES | SYROS PHARMACEUTICALS, INC. (US) | 2019-04-18 | — | — | WO | disclosed |