Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090323 | 0.77 | RAB9A (0.43) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL2091095 | 0.76 | RAB9A (0.43) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL30565139 | 0.69 | RAB9A (1.00) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL2092388 | 0.68 | KMT2A (0.43) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7165468 | 0.65 | RAB9A (0.81) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL4395297 | 0.64 | RAB9A (0.78) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL13589462 | 0.64 | NPC1 (0.78) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7128897 | 0.64 | RAB9A (0.78) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL6385934 | 0.63 | RAB9A (0.70) | RAB9ANPC1PKMSMN1; SMN2MEN1 | |
| SCHEMBL30578531 | 0.63 | RAB9A (0.70) | RAB9ANPC1PKMSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190706-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | SCANIO MARC J C (US) | 2012-07-26 | — | — | US | disclosed |
| US-8163914-B2 | Modulate neuronal nicotinic receptor activity; attention deficit disorder, Parkinson's, Tourette's, schizophrenia, cognitive deficits, dementia; acute pain, post-surgical pain, chronic pain, inflammatory pain; 2-[1-azatricyclo[3.3.1.13,7]dec-4-ylidene]-N-(4-methylphenyl)acetamide | ABBOTT LABORATORIES (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2069346-B1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | disclosed |
| US-20080255179-A1 | Acetamide and Carboxamide Derivatives of Azaadamantane and Methods of Use Thereof | ABBOTT LABORATORIES (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255179-A1 | Acetamide and Carboxamide Derivatives of Azaadamantane and Methods of Use Thereof | NAAA, AADAC, CD38 | RAB9A 3262/4885NPC1 3584/4885PKM 2536/4885 |
| US-20120190706-A1 | ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF | NAAA, AADAC, CD38 | RAB9A 3262/4885NPC1 3584/4885PKM 2536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.