Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.72 |
| ▸ | PLG | P00747 | 4/20 | 0.72 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901846 | 0.96 | PLAU (0.76) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL20912393 | 0.91 | PLAU (0.69) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL20912411 | 0.82 | PLAU (0.91) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL20912442 | 0.81 | PLAU (0.77) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL14599557 | 0.81 | PLAU (0.77) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL23566244 | 0.81 | PLAU (0.85) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL14519390 | 0.81 | PLAU (0.86) | PLAUPLGPRSS1 | |
| SCHEMBL30879664 | 0.81 | PLAU (0.80) | PLAUPLGPRSS1CHEK2 | |
| SCHEMBL5517426 | 0.80 | PLAU (0.83) | PLAUPLGPRSS1 | |
| SCHEMBL14355116 | 0.80 | PLAU (0.83) | PLAUPLGPRSS1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774049-B2 | PU.1 inhibitors | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190112276-A1 | PU.1 INHIBITORS | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2019-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774049-B2 | PU.1 inhibitors | MCL1, JUN, PUM1 | PLAU 2127/4885PLG 4045/4885PRSS1 1681/4885 |
| US-20190112276-A1 | PU.1 INHIBITORS | MCL1, JUN, PUM1 | PLAU 2127/4885PLG 4045/4885PRSS1 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.