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Sugi Predict / Compounds / SCHEMBL20915061

SCHEMBL20915061

SCHEMBL20915061

CC(C)CN(Cc1cc(Cl)c2c(c1)OCCCO2)C(=O)[C@@H]1CCN(Cc2ccc(F)c(O)c2)C1

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.66
▸ KDM4E B2RXH2 6/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ KMT2A Q03164 2/20 0.42
▸ ALDH1A1 P00352 1/20 0.38
▸ DRD2 P14416 1/20 0.38
▸ DRD4 P21917 1/20 0.38
▸ DRD3 P35462 1/20 0.38
▸ S1PR1 P21453 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ HTT P42858 3/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ PKM P14618 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ EPHX2 P34913 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564982 0.92 PROKR2 (0.66) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL565255 0.92 PROKR2 (0.69) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL10107548 0.91 PROKR2 (0.81) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL564621 0.91 PROKR2 (0.81) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL565463 0.89 PROKR2 (0.62) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL10106779 0.89 PROKR2 (0.70) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL10106784 0.89 PROKR2 (0.70) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL564933 0.89 PROKR2 (0.69) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL564923 0.89 PROKR2 (0.71) PROKR2KDM4ERAB9AKMT2AALDH1A1
SCHEMBL564942 0.88 PROKR2 (0.69) PROKR2KDM4ERAB9AKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10780095-B2 Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-09-22 — — US disclosed
US-10780095-B2 Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-09-22 — — US disclosed
US-20190117668-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF CIRCADIAN AND DIURNAL RHYTHMS USING PROKINETICIN 2 AGONISTS AND ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-04-25 — — US disclosed
US-20190117668-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF CIRCADIAN AND DIURNAL RHYTHMS USING PROKINETICIN 2 AGONISTS AND ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2019-04-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190117668-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF CIRCADIAN AND DIURNAL RHYTHMS USING PROKINETICIN 2 AGONISTS AND ANTAGONISTS PER2, PROKR2, PROKR1 PROKR2 2/4885KDM4E 3164/4885RAB9A 2373/4885
US-10780095-B2 Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists PER2, PROKR2, PROKR1 PROKR2 2/4885KDM4E 3164/4885RAB9A 2373/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.