Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR2 | Q8NFJ6 | 5/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL565158 | 1.00 | PROKR2 (0.57) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL565318 | 0.89 | PROKR2 (0.54) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10106594 | 0.89 | PROKR2 (0.54) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL565273 | 0.89 | PROKR2 (0.54) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL564997 | 0.85 | PROKR2 (0.51) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL565673 | 0.84 | PROKR2 (0.43) | PROKR2RAB9ASMN1; SMN2HTT | |
| SCHEMBL565624 | 0.83 | PROKR2 (0.56) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL564965 | 0.83 | PROKR2 (0.64) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL565598 | 0.82 | PROKR2 (0.65) | PROKR2MAPK8NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL565131 | 0.82 | PROKR2 (0.54) | PROKR2MAPK8NPC1RAB9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10780095-B2 | Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-09-22 | — | — | US | disclosed |
| US-20190117668-A1 | COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF CIRCADIAN AND DIURNAL RHYTHMS USING PROKINETICIN 2 AGONISTS AND ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117668-A1 | COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF CIRCADIAN AND DIURNAL RHYTHMS USING PROKINETICIN 2 AGONISTS AND ANTAGONISTS | PER2, PROKR2, PROKR1 | PROKR2 2/4885MAPK8 1861/4885NPC1 4117/4885 |
| US-10780095-B2 | Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists | PER2, PROKR2, PROKR1 | PROKR2 2/4885MAPK8 1861/4885NPC1 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.