Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20917270 | 0.95 | FFAR1 (0.45) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL12884217 | 0.91 | MMP2 (0.46) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL16806117 | 0.91 | MMP2 (0.46) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL16806165 | 0.91 | MMP2 (0.46) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL16806218 | 0.87 | RAB9A (0.38) | NPC1MAPTRAB9AMMP2MMP12 | |
| SCHEMBL16981596 | 0.86 | FFAR1 (0.43) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL16981593 | 0.86 | FFAR1 (0.43) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL14959962 | 0.86 | MAPT (0.47) | NPC1MAPTRAB9A | |
| SCHEMBL16806214 | 0.86 | RAB9A (0.44) | NPC1MAPTRAB9AFFAR1FFAR4 | |
| SCHEMBL16985110 | 0.85 | FFAR1 (0.42) | NPC1MAPTRAB9AFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3697768-B1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2023-06-07 | — | — | EP | disclosed |
| EP-3697768-B1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2023-06-07 | — | — | EP | disclosed |
| US-11485723-B2 | Dibenzofurans and dibenzothiophenes | MERCK PATENT GMBH (DE) | 2022-11-01 | — | — | US | disclosed |
| US-20210122725-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2021-04-29 | — | — | US | disclosed |
| US-20210122725-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2021-04-29 | — | — | US | disclosed |
| EP-3697768-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | Merck Patent GmbH (DE) | 2020-08-26 | — | — | EP | disclosed |
| WO-2019076852-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2019-04-25 | — | — | WO | disclosed |
| WO-2019076852-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | MERCK PATENT GMBH (DE) | 2019-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210122725-A1 | DIBENZOFURANS AND DIBENZOTHIOPHENES | DDT, BPTF, CCNT1 | NPC1 4260/4885MAPT 989/4885RAB9A 4330/4885 |
| US-11485723-B2 | Dibenzofurans and dibenzothiophenes | DDT, BPTF, CCNT1 | NPC1 4260/4885MAPT 989/4885RAB9A 4330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.