Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3775695 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL6692875 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372244 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL6692872 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372670 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL25212993 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL8440714 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL260176 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL20917176 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Citric Acid SCHEMBL372534 | 1.00 | CA4 (0.94) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118222223-A | Adhesive for semiconductor refrigeration sheet and preparation method and application thereof | 比亚迪股份有限公司 | 2024-06-21 | — | — | CN | claimed |
| EP-1633330-B1 | EXTENDED RELEASE OSMO-MICROSEALED FORMULATION | ALEMBIC LTD (IN) | 2007-04-04 | — | — | EP | claimed |
| CN-118222223-A | Adhesive for semiconductor refrigeration sheet and preparation method and application thereof | 比亚迪股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-112723384-B | Composite manganese-iron-based Prussian blue material and preparation method and application thereof | 电子科技大学 | 2022-05-10 | — | — | CN | disclosed |
| CN-112723384-A | Composite manganese-iron-based Prussian blue material and preparation method and application thereof | 电子科技大学 | 2021-04-30 | — | — | CN | disclosed |
| EP-0462460-B1 | Liquid composition for contact lenses method for cleaning or preserving a contact lens by means of such liquid composition | TOMEI SANGYO KK (JP) | 1996-10-16 | — | — | EP | disclosed |
| US-5460658-A | Comprising protease, polyhydric alcohol, alkali metal salt and borate mixture, soaking lens | TOMEI SANGYO KABUSHIKI KAISHA (JP) | 1995-10-24 | — | — | US | disclosed |
| EP-0462460-A2 | Liquid composition for contact lenses method for cleaning or preserving a contact lens by means of such liquid composition | Tomei Sangyo Kabushiki Kaisha (JP) | 1991-12-27 | — | — | EP | disclosed |