Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28413247 | 1.00 | GPR119 (0.42) | GPR119PIK3CDTBK1JAK2RET | |
| SCHEMBL24904180 | 0.84 | USP30 (0.46) | GPR119PIK3CDTBK1JAK2RET | |
| SCHEMBL20935188 | 0.84 | GPR119 (0.41) | GPR119TBK1JAK2RET | |
| SCHEMBL17630410 | 0.83 | TBK1 (0.44) | GPR119TBK1JAK2 | |
| SCHEMBL17630409 | 0.83 | TBK1 (0.44) | GPR119TBK1JAK2 | |
| SCHEMBL17645042 | 0.82 | TBK1 (0.43) | GPR119TBK1JAK2 | |
| SCHEMBL20918619 | 0.82 | AR (0.32) | TBK1JAK2 | |
| SCHEMBL24904176 | 0.81 | PIK3CD (0.41) | GPR119PIK3CDTBK1JAK2 | |
| SCHEMBL20934896 | 0.79 | GPR119 (0.40) | GPR119TBK1JAK2RET | |
| SCHEMBL22582845 | 0.77 | GPR119 (0.51) | GPR119JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3697772-A1 | PYRIMIDINE TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2020-08-26 | — | — | EP | disclosed |
| WO-2019079373-A1 | PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-04-25 | — | — | WO | disclosed |