Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.59 |
| ▸ | CTSV | O60911 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 2/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21828647 | 0.92 | CTSV (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL155013 | 0.89 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL29540314 | 0.89 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL30272743 | 0.81 | CTSV (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL30272742 | 0.81 | CTSV (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL30272741 | 0.81 | CTSV (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL151534 | 0.81 | CTSV (0.79) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL12722533 | 0.79 | MAPT (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL17396637 | 0.79 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA2 | |
| SCHEMBL30272747 | 0.79 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019076336-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2019-04-25 | — | — | WO | disclosed |