Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145692 | 0.84 | MAPK8 (0.57) | MAPK8MAPK9RECQLKDM4EALDH1A1 | |
| SCHEMBL2673753 | 0.81 | RECQL (0.71) | RECQLPOLBTSHRMAPK1KDM4E | |
| SCHEMBL20606873 | 0.81 | MAPK8 (0.59) | MAPK8MAPK9MAPK1PRKD3MAP4K4 | |
| SCHEMBL15173851 | 0.80 | RECQL (0.54) | MAPK8MAPK9RECQLPOLBTSHR | |
| SCHEMBL15174110 | 0.79 | RECQL (0.53) | MAPK8MAPK9RECQLPOLBTSHR | |
| SCHEMBL16212460 | 0.79 | RECQL (0.53) | MAPK8MAPK9RECQLPOLBTSHR | |
| SCHEMBL26709049 | 0.76 | POLB (0.43) | MAPK8MAPK9RECQLPOLBTSHR | |
| SCHEMBL16401899 | 0.76 | RECQL (0.50) | MAPK8MAPK9RECQLPOLBTSHR | |
| SCHEMBL16401095 | 0.76 | RECQL (0.50) | MAPK8MAPK9RECQLPOLBTSHR | |
| SCHEMBL17163957 | 0.75 | RECQL (0.67) | MAPK8MAPK9RECQLPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | Mirati Therapeutics, Inc. (US) | 2019-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266542-B2 | EZH2 inhibitors | EZH2, BMI1, EED | MAPK8 1635/4885MAPK9 1134/4885RECQL 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.