Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.59 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.59 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.59 |
| ▸ | RPS27 | P42677 | 5/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1145009 | 0.85 | MAPK8 (0.60) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL9820174 | 0.83 | ALDH1A1 (0.57) | MAPK1 | |
| SCHEMBL1145693 | 0.83 | MAPK8 (0.61) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL20920951 | 0.81 | MAPK8 (0.56) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL18556082 | 0.81 | POLB (0.48) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL13514366 | 0.80 | MAPK8 (0.55) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1146017 | 0.78 | MAPK8 (0.74) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL1145329 | 0.78 | MAPK8 (0.74) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL20606816 | 0.78 | POLB (0.40) | MAPK8MAPK9MAPK10PRKD3PRKD2 | |
| SCHEMBL3064069 | 0.77 | MAPK8 (0.49) | MAPK8MAPK9MAPK10PRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |
| EP-3423445-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | Galapagos NV (BE) | 2019-01-09 | — | — | EP | disclosed |