Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 15/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19879996 | 0.89 | PRF1 (0.59) | PRF1DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL20924158 | 0.86 | PRF1 (0.57) | PRF1 | |
| SCHEMBL15571390 | 0.85 | PRF1 (0.58) | PRF1GRM5OPRD1MEN1KMT2A | |
| SCHEMBL2043120 | 0.84 | PRF1 (0.66) | PRF1GRM5OPRD1MEN1KMT2A | |
| SCHEMBL15570786 | 0.81 | PRF1 (0.58) | PRF1 | |
| SCHEMBL14761067 | 0.80 | PRF1 (0.53) | PRF1GRM5OPRD1MEN1KMT2A | |
| SCHEMBL16561641 | 0.79 | OPRD1 (0.56) | PRF1GRM5OPRD1MEN1KMT2A | |
| SCHEMBL15570926 | 0.78 | DRD2 (0.52) | PRF1GRM5OPRD1DRD2DRD3 | |
| SCHEMBL16970857 | 0.78 | PRF1 (0.62) | PRF1 | |
| SCHEMBL20924249 | 0.78 | PRF1 (0.57) | PRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888251-B1 | PERFORIN INHIBITING BENZENESULFONAMIDE COMPOUNDS, PREPARATION AND USES THEREOF | PETER MACCALLUM CANCER INST (AU) | 2019-04-24 | — | — | EP | disclosed |