SCHEMBL20924129

SCHEMBL20924129

N#Cc1ccccc1-c1ccc2c3ccc(-c4ccccc4C#N)cc3n(-c3cc(C#N)c(-c4ccncc4)cc3-c3ccccc3)c2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.41
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39
NR3C1 P04150 1/20 0.38
ESR2 Q92731 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HIF1A Q16665 1/20 0.38
PDE10A Q9Y233 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA5 P31644 1/20 0.38
GABRA3 P34903 1/20 0.38
SQOR Q9Y6N5 1/20 0.37
CYP19A1 P11511 3/20 0.37
XDH P47989 1/20 0.37
CDC7 O00311 1/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20923721 0.97 TRPA1 (0.39) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL20923146 0.96 GSK3A (0.39) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL20924032 0.93 PDE10A (0.38) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL19919602 0.92 TRPA1 (0.43) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL20923324 0.91 NR3C1 (0.40) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL19919613 0.91 TRPA1 (0.43) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL20924126 0.90 AR (0.40) SMN1; SMN2HIF1ASQORXDHCYP1A2
SCHEMBL20924133 0.90 TRPA1 (0.39) TRPA1GSK3AGSK3BNR3C1ESR2
SCHEMBL20923834 0.90 CYP11B1 (0.40) SQORCYP19A1XDHCYP1A2CYP2C9
SCHEMBL19909024 0.89 TRPA1 (0.41) TRPA1GSK3AGSK3BNR3C1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3266772-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-04-24 EP disclosed