Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20928367 | 0.80 | ADORA2A (0.56) | EGFRKITRIPK1 | |
| SCHEMBL20928159 | 0.80 | MITF (0.47) | EGFRKITRIPK1CDC7PIM1 | |
| SCHEMBL12330482 | 0.80 | CCNB2 (0.61) | EGFRKITRIPK1 | |
| SCHEMBL20928271 | 0.78 | KIT (0.42) | EGFRKITRIPK1CDC7PIM1 | |
| SCHEMBL20927913 | 0.74 | PIK3C3 (0.51) | EGFRKIT | |
| SCHEMBL20927979 | 0.73 | CDK1 (0.40) | — | |
| SCHEMBL20927793 | 0.72 | PRMT5 (0.45) | KITRIPK1 | |
| SCHEMBL20927803 | 0.72 | AURKA (0.56) | KIT | |
| SCHEMBL4155195 | 0.72 | NR4A2 (0.54) | EGFR | |
| SCHEMBL31119539 | 0.70 | IKBKB (0.47) | KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079649-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION (US) | 2019-04-25 | — | — | WO | disclosed |