Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24375404 | 0.83 | PTH1R (0.33) | MAPTPTH1RMAP4K4 | |
| SCHEMBL20934767 | 0.83 | FPR2 (0.37) | MAPTGAARAB9AALDH1A1L3MBTL1 | |
| SCHEMBL180817 | 0.77 | APP (0.55) | APPMAPTMAOAMAOBGAA | |
| Hydrochloric Acid SCHEMBL4952599 | 0.74 | APP (0.53) | APPMAPTMAOAMAOBGAA | |
| SCHEMBL24030297 | 0.74 | DDB1 (0.39) | APPMAPTGAAEPHX1RAB9A | |
| SCHEMBL20934859 | 0.73 | MAPT (0.37) | MAPTPTH1RALDH1A1 | |
| SCHEMBL5155907 | 0.71 | APP (0.50) | APPMAPTMAOAMAOBGAA | |
| Hydrochloric Acid SCHEMBL5467007 | 0.69 | APP (0.48) | APPMAPTMAOAMAOBGAA | |
| SCHEMBL2024986 | 0.68 | MAPT (0.56) | APPMAPTMAOAMAOBRAB9A | |
| SCHEMBL34107 | 0.68 | PRSS1 (0.54) | APPMAPTMAOAMAOBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079373-A1 | PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-04-25 | — | — | WO | disclosed |