Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20934880 | 0.83 | APP (0.39) | MAPTL3MBTL1ALDH1A1GAARAB9A | |
| SCHEMBL11531629 | 0.77 | MAPT (0.55) | MAPTAGERKMT2AMEN1LMNA | |
| SCHEMBL24375404 | 0.76 | PTH1R (0.33) | MAPTDRD2DRD3DRD4 | |
| SCHEMBL22864457 | 0.74 | FPR2 (0.42) | FPR2POLBKMT2AMEN1LMNA | |
| SCHEMBL20934859 | 0.73 | MAPT (0.37) | MAPTALDH1A1 | |
| SCHEMBL30314739 | 0.71 | AGER (0.45) | MAPTAGERDRD2DRD3DRD1 | |
| SCHEMBL24123583 | 0.66 | MAPT (0.65) | MAPTPOLBKMT2AMEN1L3MBTL1 | |
| SCHEMBL1947781 | 0.65 | AGER (0.44) | MAPTAGERKMT2AMEN1LMNA | |
| SCHEMBL1554174 | 0.65 | CYP1A2 (0.53) | MAPTAGERKMT2AMEN1LMNA | |
| SCHEMBL3041532 | 0.65 | AGER (0.48) | FPR2MAPTAGERKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079373-A1 | PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-04-25 | — | — | WO | disclosed |