Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23347014 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2NAMPTNAAATTRIL2 | |
| SCHEMBL6849179 | 0.89 | PTGS1 (0.47) | SMN1; SMN2NAMPTNAAATTRIL2 | |
| SCHEMBL20936573 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2NAMPTNAAATTRIL2 | |
| SCHEMBL21659263 | 0.86 | NAMPT (0.42) | SMN1; SMN2NAMPTNAAATTRIL2 | |
| SCHEMBL14872066 | 0.85 | NAAA (0.55) | SMN1; SMN2NAAALMNAGNAI3GNAO1 | |
| SCHEMBL2779228 | 0.85 | NAAA (0.55) | SMN1; SMN2NAAALMNAGNAI3GNAO1 | |
| SCHEMBL21118924 | 0.85 | SMN1; SMN2 (0.40) | SMN1; SMN2NAMPTNAAATTRIL2 | |
| SCHEMBL20841156 | 0.85 | SMN1; SMN2 (0.40) | SMN1; SMN2NAMPTNAAATTRIL2 | |
| SCHEMBL19703683 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2NAAALMNAGNAI3GNAO1 | |
| SCHEMBL17739999 | 0.84 | NAAA (0.48) | SMN1; SMN2NAAALMNAGNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2019079357-A1 | TNIK MODULATORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |