Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 9/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15554584 | 0.74 | PPP5C (0.53) | ACKR3KCNH2 | |
| SCHEMBL20381220 | 0.71 | HSD11B1 (0.54) | HSD11B1ACKR3KCNH2 | |
| SCHEMBL9376106 | 0.69 | KDM4E (0.44) | — | |
| SCHEMBL8067270 | 0.69 | KDM4E (0.44) | — | |
| SCHEMBL3259183 | 0.69 | KDM4E (0.44) | — | |
| SCHEMBL3211316 | 0.69 | MEN1 (0.36) | — | |
| SCHEMBL3465697 | 0.69 | KDM4E (0.44) | — | |
| SCHEMBL13795024 | 0.69 | KDM4E (0.44) | — | |
| SCHEMBL8246038 | 0.69 | KDM4E (0.44) | — | |
| SCHEMBL4738730 | 0.69 | KDM4E (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079783-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2019-04-25 | — | — | WO | disclosed |