Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.47 |
| ▸ | GSK3B | P49841 | 19/20 | 0.47 |
| ▸ | WNT1 | P04628 | 9/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20938652 | 0.81 | DYRK1A (0.48) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL24219354 | 0.79 | DYRK1A (0.46) | DYRK1AGSK3BWNT1 | |
| SCHEMBL20938647 | 0.76 | DYRK1A (0.45) | DYRK1AGSK3BWNT1 | |
| SCHEMBL24219238 | 0.76 | DYRK1A (0.51) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938746 | 0.73 | DYRK1A (0.46) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938744 | 0.72 | DYRK1A (0.46) | DYRK1AGSK3BWNT1 | |
| SCHEMBL24219690 | 0.71 | GSK3B (0.48) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938656 | 0.71 | DYRK1A (0.50) | DYRK1AGSK3BWNT1 | |
| SCHEMBL24218995 | 0.70 | DYRK1A (0.43) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938540 | 0.69 | DYRK1A (0.43) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079626-A1 | 6-(5-MEMBERED HETEROARYL)ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED, LLC (US) | 2019-04-25 | — | — | WO | disclosed |