Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.50 |
| ▸ | GSK3B | P49841 | 18/20 | 0.50 |
| ▸ | WNT1 | P04628 | 4/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20938647 | 0.84 | DYRK1A (0.45) | DYRK1AGSK3BWNT1 | |
| SCHEMBL20938744 | 0.80 | DYRK1A (0.46) | DYRK1AGSK3BWNT1CCNKCCNA2 | |
| SCHEMBL20938652 | 0.79 | DYRK1A (0.48) | DYRK1AGSK3BWNT1CCNKCCNA2 | |
| SCHEMBL20938540 | 0.79 | DYRK1A (0.43) | DYRK1AGSK3BWNT1CCNKCCNA2 | |
| SCHEMBL20938729 | 0.77 | GSK3B (0.44) | DYRK1AGSK3BWNT1 | |
| SCHEMBL20938510 | 0.71 | DYRK1A (0.47) | DYRK1AGSK3BWNT1 | |
| SCHEMBL20968590 | 0.71 | GSK3B (0.59) | DYRK1AGSK3B | |
| SCHEMBL23741148 | 0.71 | HCAR3 (0.36) | DYRK1AGSK3BWNT1 | |
| SCHEMBL20968462 | 0.68 | DYRK1A (0.67) | DYRK1AGSK3B | |
| SCHEMBL20938538 | 0.68 | DYRK1A (0.49) | DYRK1AGSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019079626-A1 | 6-(5-MEMBERED HETEROARYL)ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED, LLC (US) | 2019-04-25 | — | — | WO | disclosed |