⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757755 | 0.83 | — | — | |
| SCHEMBL21883665 | 0.83 | — | — | |
| SCHEMBL19013814 | 0.83 | — | — | |
| SCHEMBL7479191 | 0.80 | — | — | |
| SCHEMBL26743215 | 0.78 | CHRNB2 (0.32) | — | |
| SCHEMBL9944701 | 0.77 | — | — | |
| SCHEMBL26743375 | 0.76 | CHRNB2 (0.31) | — | |
| SCHEMBL26743387 | 0.75 | ALOX15 (0.32) | — | |
| SCHEMBL16316868 | 0.75 | CHRNB2 (0.38) | — | |
| SCHEMBL12638492 | 0.75 | CHRNB2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180487-B2 | Substituted cyanoindoline derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-23 | — | — | US | disclosed |
| US-20190119299-A1 | CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-04-25 | — | — | US | disclosed |