Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20942536 | 0.89 | TAF1 (0.60) | TAF1BRD4RAB9AMAPTNPC1 | |
| SCHEMBL30402413 | 0.86 | TAF1 (0.65) | TAF1BRD4RAB9AMAPTNPC1 | |
| SCHEMBL20942542 | 0.86 | TAF1 (0.65) | TAF1BRD4RAB9AMAPTNPC1 | |
| SCHEMBL20942538 | 0.82 | NPC1 (0.60) | TAF1BRD4RAB9AMAPTNPC1 | |
| SCHEMBL20942626 | 0.81 | TAF1 (0.76) | TAF1RAB9AMAOBMAPTNPC1 | |
| SCHEMBL19276494 | 0.76 | NPC1 (0.58) | BRD4L3MBTL1POLBRAB9ANPC1 | |
| SCHEMBL20942558 | 0.76 | TAF1 (0.60) | TAF1RAB9AMAPTNPC1TP53 | |
| SCHEMBL19276574 | 0.74 | BRD4 (0.52) | BRD4L3MBTL1POLBRAB9AMAPT | |
| SCHEMBL19276575 | 0.73 | BRD4 (0.60) | BRD4L3MBTL1POLBRAB9AMAOB | |
| SCHEMBL20942498 | 0.73 | POLB (0.82) | BRD4L3MBTL1POLBRAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10702518-B2 | TAF1 inhibitors for the therapy of cancer | CeMM—FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH (AT) | 2020-07-07 | — | — | US | disclosed |
| US-20190117641-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117641-A1 | TAF1 INHIBITORS FOR THE THERAPY OF CANCER | TAF1, TAF1L, TAF5 | TAF1 1/4885BRD4 27/4885L3MBTL1 2669/4885 |
| US-10702518-B2 | TAF1 inhibitors for the therapy of cancer | TAF1, TAF1L, TAF5 | TAF1 1/4885BRD4 27/4885L3MBTL1 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.