Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6ST | P40189 | 6/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20943427 | 1.00 | IL6ST (0.55) | IL6STSTAT3NAAA | |
| SCHEMBL22261830 | 0.71 | IL6ST (1.00) | IL6STSTAT3NAAA | |
| SCHEMBL22261831 | 0.71 | IL6ST (1.00) | IL6STSTAT3NAAA | |
| SCHEMBL23926079 | 0.61 | CES2 (0.40) | — | |
| SCHEMBL10903055 | 0.56 | AKR1B1 (0.48) | — | |
| SCHEMBL10594885 | 0.56 | AKR1B1 (0.48) | — | |
| SCHEMBL14091098 | 0.56 | — | — | |
| SCHEMBL19057211 | 0.56 | CES2 (0.42) | — | |
| SCHEMBL31519438 | 0.56 | IL6ST (0.65) | IL6STSTAT3NAAA | |
| SCHEMBL25110725 | 0.55 | CES2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700514-B1 | COMBINATION OF IL-8 INHIBITORS AND IL-6/GP-130 INHIBITORS FOR USE IN THE TREATMENT OF LUNG METASTASIS ASSOCIATED TO OSTEOSARCOMA | DOMPE FARM SPA (IT) | 2025-03-19 | — | — | EP | claimed |
| EP-4548916-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME SARCOMAS | Dompé farmaceutici SpA (IT) | 2025-05-07 | — | — | EP | disclosed |
| EP-3700514-B1 | COMBINATION OF IL-8 INHIBITORS AND IL-6/GP-130 INHIBITORS FOR USE IN THE TREATMENT OF LUNG METASTASIS ASSOCIATED TO OSTEOSARCOMA | DOMPE FARM SPA (IT) | 2025-03-19 | — | — | EP | disclosed |
| US-11660291-B2 | IL-8 inhibitors for use in the treatment of some sarcomas | DOMPE' FARMACEUTICI S.P.A. (IT) | 2023-05-30 | — | — | US | disclosed |
| US-20210361627-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME SARCOMAS | DOMPE' FARMACEUTICI (IT) | 2021-11-25 | — | — | US | disclosed |
| EP-3700514-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME SARCOMAS | Dompé farmaceutici S.p.A. (IT) | 2020-09-02 | — | — | EP | disclosed |
| EP-3476390-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SARCOMAS | Dompé farmaceutici S.p.A. (IT) | 2019-05-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210361627-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT OF SOME SARCOMAS | CXCL8, CXCR1, CXCR2 | IL6ST 25/4885STAT3 173/4885NAAA 4287/4885 |
| US-11660291-B2 | IL-8 inhibitors for use in the treatment of some sarcomas | CXCL8, CXCR1, CXCR2 | IL6ST 25/4885STAT3 173/4885NAAA 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.