Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675891 | 0.82 | CHEK1 (0.58) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL3004142 | 0.71 | CHEK1 (1.00) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL13122682 | 0.70 | CHEK1 (0.63) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL13122699 | 0.69 | CHEK1 (0.58) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL30040295 | 0.68 | CHEK1 (0.66) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL15866141 | 0.68 | CHEK1 (0.66) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL20024820 | 0.67 | IDO1 (0.38) | CYP1A2CYP2A6SLC6A4KDM4EPOLB | |
| SCHEMBL20674191 | 0.66 | CHEK1 (0.63) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL29361454 | 0.66 | CHEK1 (0.63) | CHEK1FLT3PLK3ADRA2ANOS1 | |
| SCHEMBL17515574 | 0.66 | CHEK1 (0.58) | CHEK1FLT3PLK3ADRA2ANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | CHEK1 2734/4885FLT3 577/4885PLK3 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.