Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20958939 | 0.74 | HSD17B10 (0.39) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL20959623 | 0.73 | KDM4E (0.39) | KDM4ETDP1POLBMAPTALDH1A1 | |
| SCHEMBL15591888 | 0.72 | SSTR4 (0.67) | HPGDSSTR4KMT2ASMN1; SMN2 | |
| SCHEMBL25417616 | 0.71 | ALDH1A1 (0.39) | KDM4ETDP1POLBMAPTALDH1A1 | |
| SCHEMBL16103438 | 0.68 | MAPK14 (0.49) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL21243395 | 0.66 | SSTR4 (0.40) | ALDH1A1GAASSTR4KMT2ATSHR | |
| SCHEMBL21986316 | 0.66 | ALDH1A1 (0.55) | POLBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL12185196 | 0.65 | PIM1 (0.46) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL25420616 | 0.64 | CCR5 (0.41) | TDP1ALDH1A1HSD17B10HPGDCCR5 | |
| Trifluoroacetic Acid SCHEMBL30241558 | 0.64 | SSTR4 (0.41) | KDM4ETDP1ALDH1A1HPGDSSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10435399-B2 | HDAC6 inhibitory heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-10-08 | — | — | US | disclosed |
| US-20190135799-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435399-B2 | HDAC6 inhibitory heterocyclic compound | HDAC6, HDAC1, HDAC5 | KDM4E 522/4885TDP1 1318/4885POLB 3132/4885 |
| US-20190135799-A1 | HETEROCYCLIC COMPOUND | HDAC1, HDAC5, HDAC6 | KDM4E 216/4885TDP1 817/4885POLB 3716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.