Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.60 |
| ▸ | AR | P10275 | 4/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demegestone SCHEMBL6851326 | 0.89 | PGR (0.78) | PGRNR3C1ARNR3C2ESR1 | |
| Demegestone SCHEMBL1649297 | 0.89 | PGR (0.78) | PGRNR3C1ARNR3C2ESR1 | |
| Demegestone SCHEMBL146550 | 0.89 | PGR (0.78) | PGRNR3C1ARNR3C2ESR1 | |
| Demegestone SCHEMBL28338894 | 0.87 | PGR (0.75) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL19286040 | 0.86 | PGR (0.74) | PGRNR3C1ARNR3C2ESR1 | |
| Promegestone SCHEMBL37770 | 0.86 | PGR (1.00) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL21231223 | 0.85 | PGR (0.70) | PGRNR3C1ARNR3C2ESR1 | |
| SCHEMBL13875044 | 0.85 | PGR (0.70) | PGRNR3C1ARNR3C2ESR1 | |
| Trimegestone SCHEMBL17906556 | 0.85 | PGR (0.72) | PGRNR3C1ARNR3C2ESR1 | |
| Trimegestone SCHEMBL13752884 | 0.85 | PGR (0.72) | PGRNR3C1ARNR3C2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632471-B1 | TRIMEGESTONE (TMG) FOR TREATMENT OF PRETERM BIRTH | DIGNITY HEALTH (US) | 2019-05-01 | — | — | EP | disclosed |