Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24308808 | 0.89 | NAMPT (0.42) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL24308809 | 0.82 | NAMPT (0.40) | NAMPTTPSAB1TPSD1TPSG1HSD17B10 | |
| SCHEMBL19195102 | 0.80 | AKR1C3 (0.38) | ALDH1A1KDM4EHSD17B10NPC1HSD11B1 | |
| SCHEMBL16838103 | 0.79 | NAMPT (0.56) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL3711838 | 0.76 | NAMPT (0.56) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL20328000 | 0.76 | HSD11B1 (0.58) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL15076642 | 0.75 | NAMPT (0.51) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL20084011 | 0.75 | NAMPT (0.51) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL20970620 | 0.75 | NAMPT (0.51) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 | |
| SCHEMBL13451572 | 0.75 | ALDH1A1 (0.62) | NAMPTTPSAB1TPSD1TPSG1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127374-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127374-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | NAMPT 3149/4885TPSAB1 3441/4885TPSD1 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.