Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 4/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.54 |
| ▸ | MDM4 | O15151 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19454011 | 0.94 | TLR2 (0.51) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL31191799 | 0.91 | CASP3 (0.53) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL13402594 | 0.89 | TLR2 (0.64) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL30063023 | 0.89 | TLR2 (0.64) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL30802520 | 0.89 | TLR2 (0.64) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL14996025 | 0.89 | TLR2 (0.64) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL14497949 | 0.89 | TLR2 (0.64) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL30564479 | 0.89 | TLR2 (0.64) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL14024490 | 0.89 | MDM2 (0.53) | TLR2MDM2MDM4TP53CASP3 | |
| SCHEMBL800121 | 0.89 | MDM2 (0.56) | TLR2MDM2MDM4TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220526-B2 | Neuropeptide S receptor (NPSR) agonists | RESEARCH TRIANGLE INSTITUTE (US) | 2022-01-11 | — | — | US | disclosed |
| US-20190127419-A1 | NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS | RESEARCH TRIANGLE INSTITUTE | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127419-A1 | NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS | NPSR1, GRPR, NPBWR1 | TLR2 1090/4885MDM2 4634/4885MDM4 4756/4885 |
| US-11220526-B2 | Neuropeptide S receptor (NPSR) agonists | NPSR1, GRPR, NPBWR1 | TLR2 1090/4885MDM2 4634/4885MDM4 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.