Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | CPA2 | P48052 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20964452 | 0.96 | CALCRL (0.57) | CALCRLITGB3ITGA2BKISS1RGRIA1 | |
| SCHEMBL20964480 | 0.91 | CALCRL (0.63) | CALCRLROCK2ITGB3ITGA2BKISS1R | |
| SCHEMBL20964475 | 0.87 | CALCRL (0.52) | CALCRLROCK2KISS1RCHRNB2CHRNB4 | |
| SCHEMBL20964497 | 0.86 | CALCRL (0.58) | CALCRLITGB3ITGA2BF2KISS1R | |
| SCHEMBL16908006 | 0.86 | HDAC2 (0.51) | ITGB3ITGA2B | |
| SCHEMBL30687362 | 0.86 | HDAC2 (0.51) | ITGB3ITGA2B | |
| SCHEMBL20964425 | 0.86 | CALCRL (0.53) | CALCRLKISS1RCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20964453 | 0.85 | PTPN1 (0.57) | CALCRLITGB3ITGA2BGRIA1PRSS1 | |
| SCHEMBL20964479 | 0.85 | CALCRL (0.52) | CALCRLKISS1RHRH1 | |
| SCHEMBL10088317 | 0.84 | ITGB3 (0.55) | CALCRLITGB3ITGA2BF2ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220526-B2 | Neuropeptide S receptor (NPSR) agonists | RESEARCH TRIANGLE INSTITUTE (US) | 2022-01-11 | — | — | US | disclosed |
| US-20190127419-A1 | NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS | RESEARCH TRIANGLE INSTITUTE | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127419-A1 | NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS | NPSR1, GRPR, NPBWR1 | CALCRL 116/4885ROCK2 4539/4885ITGB3 2656/4885 |
| US-11220526-B2 | Neuropeptide S receptor (NPSR) agonists | NPSR1, GRPR, NPBWR1 | CALCRL 116/4885ROCK2 4539/4885ITGB3 2656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.