Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023162 | 0.88 | HPGD (0.50) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL19781758 | 0.87 | NLRP3 (0.53) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL28578207 | 0.85 | NLRP3 (0.46) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL2096563 | 0.83 | NLRP3 (0.56) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL19779388 | 0.82 | NLRP3 (0.44) | NLRP3ALDH1A1L3MBTL1ATMMAPT | |
| SCHEMBL9359788 | 0.82 | NLRP3 (0.78) | NLRP3ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL24574915 | 0.80 | LCK (0.60) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL28422693 | 0.80 | NLRP3 (0.53) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL30051979 | 0.79 | MAPT (0.67) | ALDH1A1L3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL4333871 | 0.79 | POLB (0.60) | NLRP3ALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079383-A | With A Methylating Agent Using A Zinc Halide Catalyst | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-01-07 | — | — | US | claimed |
| EP-0325620-A1 | METHOD FOR THE PREPARATION OF AMIDINO-UREA DERIVATIVES | REANAL FINOMVEGYSZERGYAR (HU) | 1989-08-02 | — | — | EP | claimed |
| WO-1988007990-A1 | METHOD FOR THE PREPARATION OF AMIDINO-UREA DERIVATIVES | REANAL FINOMVEGYSZERGYÁR (HU) | 1988-10-20 | — | — | WO | claimed |
| US-10316008-B2 | KCNQ potassium channel agonist, and preparation method therefor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-06-11 | — | — | US | disclosed |
| US-20180134677-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-05-17 | — | — | US | disclosed |
| US-20180134677-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-05-17 | — | — | US | disclosed |
| US-20170081301-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONISTS, METHOD OF PREPARATION AND METHOD OF USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-03-23 | — | — | US | disclosed |
| US-20170081301-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONISTS, METHOD OF PREPARATION AND METHOD OF USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-03-23 | — | — | US | disclosed |
| EP-3138833-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2017-03-08 | — | — | EP | disclosed |
| US-8163753-B2 | 2-(4-(4-(4-chlorophenyl)oxazol-2-yl)phenoxymethyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole; bactericide; excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |
| WO-1988007990-A1 | METHOD FOR THE PREPARATION OF AMIDINO-UREA DERIVATIVES | REANAL FINOMVEGYSZERGYÁR (HU) | 1988-10-20 | — | — | WO | disclosed |
| EP-0110732-B1 | PROCESS FOR PRODUCING DIPHENYLMETHANE DICARBAMATES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1987-03-11 | — | — | EP | disclosed |
| EP-0123412-B1 | METHOD FOR MANUFACTURE OF DIPHENYLMETHANE DIISOCYANATES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1986-07-09 | — | — | EP | disclosed |
| US-4552974-A | Process for producing diphenylmethane dicarbamates | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-11-12 | — | — | US | disclosed |
| US-4547322-A | Method for manufacture of diphenylmethane diisocyanates | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-10-15 | — | — | US | disclosed |
| EP-0123412-A1 | Method for manufacture of diphenylmethane diisocyanates | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-31 | — | — | EP | disclosed |
| EP-0110732-A2 | Process for producing diphenylmethane dicarbamates | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-06-13 | — | — | EP | disclosed |
| US-4328354-A | Preparation of methylene-bis-phenylcarbamic acid esters and polymethylene-polyphenylcarbamic acid esters | BASF AKTIENGESELLSCHAFT (DE) | 1982-05-04 | — | — | US | disclosed |
| US-4282370-A | Preparation of methylene-bis-phenylcarbamic acid esters and of polymethylene-polyphenylcarbamic acid esters | BASF AKTIENGESELLSCHAFT (DE) | 1981-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134677-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | KCNQ5, KCNQ4, KCNQ1 | NLRP3 726/4885ALDH1A1 2001/4885L3MBTL1 3644/4885 |
| US-10316008-B2 | KCNQ potassium channel agonist, and preparation method therefor and use thereof | KCNQ5, KCNQ4, KCNQ3 | NLRP3 740/4885ALDH1A1 1958/4885L3MBTL1 3631/4885 |
| US-20170081301-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONISTS, METHOD OF PREPARATION AND METHOD OF USE THEREOF | KCNQ5, KCNQ4, KCNQ3 | NLRP3 963/4885ALDH1A1 1690/4885L3MBTL1 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.