Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 2/20 | 0.85 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | HRH2 | P25021 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363355 | 0.92 | MITF (1.00) | MITFHTTL3MBTL1NPSR1MAPK1 | |
| SCHEMBL17348173 | 0.92 | HTT (0.74) | MITFHTTL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL20979246 | 0.91 | HTT (0.72) | MITFHTTL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL18782441 | 0.89 | MITF (0.78) | MITFHTTL3MBTL1MAPK1MAPT | |
| SCHEMBL17348101 | 0.88 | MITF (0.78) | MITFHTTL3MBTL1ALDH1A1MAPT | |
| SCHEMBL17348136 | 0.86 | MITF (0.81) | MITFHTTL3MBTL1MAPK1MAPT | |
| SCHEMBL2363171 | 0.86 | MITF (1.00) | MITFHTTALDH1A1NPSR1MAPT | |
| SCHEMBL17348102 | 0.85 | HTT (0.77) | MITFHTTL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL18782230 | 0.84 | MITF (0.78) | MITFHTTL3MBTL1MAPK1MAPT | |
| SCHEMBL18782191 | 0.84 | CHRM5 (0.85) | MITFHTTL3MBTL1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154966-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | US HEALTH (US) | 2019-05-08 | — | — | EP | disclosed |