Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 12/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29315212 | 0.78 | GRM4 (0.42) | GRM4CTSKCTSLCTSBMMP9 | |
| SCHEMBL11290575 | 0.77 | GRM4 (0.41) | GRM4CTSKCTSLCTSBMMP9 | |
| SCHEMBL7066347 | 0.77 | GRM4 (0.41) | GRM4CTSKCTSLCTSBMMP9 | |
| SCHEMBL30606190 | 0.77 | GRM4 (0.39) | GRM4CTSKCTSLCTSBMMP9 | |
| SCHEMBL29315213 | 0.76 | CA1 (0.47) | GRM4CTSKCTSLCTSB | |
| SCHEMBL5909473 | 0.74 | GRM4 (0.56) | GRM4CTSKCTSB | |
| SCHEMBL26344988 | 0.74 | GRM4 (0.45) | GRM4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29315215 | 0.73 | BCHE (0.39) | GRM4CTSK | |
| SCHEMBL10169316 | 0.73 | GRM4 (0.39) | GRM4CTSKCTSLCTSB | |
| SCHEMBL14086000 | 0.71 | EPHX1 (0.50) | GRM4PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970335-B1 | MACROCYCLIC AND BICYCLIC INHIBITORS OF HEPATITIS C VIRUS | GILEAD SCIENCES INC (US) | 2019-05-08 | — | — | EP | disclosed |