Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 9/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29315212 | 0.82 | GRM4 (0.42) | GRM4CTSKCTSLCTSBMMP9 | |
| SCHEMBL11290575 | 0.81 | GRM4 (0.41) | GRM4CTSKEPHX1HSD17B10CTSL | |
| SCHEMBL29315213 | 0.79 | CA1 (0.47) | GRM4CTSKEPHX1CTSLCTSB | |
| SCHEMBL5909473 | 0.79 | GRM4 (0.56) | GRM4CTSKEPHX1SMN1; SMN2CTSB | |
| SCHEMBL13918262 | 0.77 | SLC6A2 (0.42) | GABRR1GABRR2EPHX1SMN1; SMN2 | |
| SCHEMBL15888749 | 0.77 | SLC6A2 (0.42) | GABRR1GABRR2EPHX1SMN1; SMN2 | |
| SCHEMBL20979462 | 0.77 | GRM4 (0.38) | GRM4CTSKCTSLCTSBMMP9 | |
| SCHEMBL30606190 | 0.77 | GRM4 (0.39) | GRM4CTSKEPHX1SMN1; SMN2HSD17B10 | |
| SCHEMBL29315215 | 0.77 | BCHE (0.39) | GRM4CTSKEPHX1 | |
| SCHEMBL10169316 | 0.77 | GRM4 (0.39) | GRM4CTSKEPHX1SMN1; SMN2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313696-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018323-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-07 | — | — | WO | disclosed |