⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748293 | 0.78 | ALDH1A1 (0.31) | — | |
| SCHEMBL22661082 | 0.76 | BCHE (0.31) | — | |
| SCHEMBL14336264 | 0.76 | MCL1 (0.34) | — | |
| SCHEMBL19414066 | 0.74 | KMT2A (0.41) | — | |
| SCHEMBL23177698 | 0.73 | HPGD (0.44) | — | |
| SCHEMBL26209775 | 0.73 | ALDH1A1 (0.40) | — | |
| SCHEMBL23729380 | 0.72 | ALDH1A1 (0.39) | — | |
| SCHEMBL25588296 | 0.71 | CTSK (0.30) | — | |
| SCHEMBL13965302 | 0.71 | POLB (0.45) | — | |
| SCHEMBL25980958 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230279020-A9 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2023-09-07 | — | — | US | disclosed |
| US-20210155631-A1 | CARM1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2021-05-27 | — | — | US | disclosed |
| US-10633389-B2 | CARM1 inhibitors and uses thereof | Epizyme, Inc. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190135819-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2019-05-09 | — | — | US | disclosed |