Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | STING1 | Q86WV6 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921783 | 1.00 | ALDH1A1 (0.66) | ALDH1A1NPSR1SMN1; SMN2MDM2TP53 | |
| SCHEMBL2099808 | 0.90 | MDM2 (0.75) | ALDH1A1NPSR1SMN1; SMN2MDM2TP53 | |
| SCHEMBL29921815 | 0.90 | MDM2 (0.75) | ALDH1A1NPSR1SMN1; SMN2MDM2TP53 | |
| SCHEMBL29921547 | 0.81 | MDM2 (0.55) | ALDH1A1NPSR1SMN1; SMN2MDM2TP53 | |
| SCHEMBL2098925 | 0.81 | MDM2 (0.55) | ALDH1A1NPSR1SMN1; SMN2MDM2TP53 | |
| SCHEMBL2098416 | 0.80 | MDM2 (0.67) | ALDH1A1MDM2STING1RAB9AHSD17B10 | |
| SCHEMBL17317367 | 0.80 | MDM2 (0.67) | ALDH1A1MDM2STING1RAB9AHSD17B10 | |
| SCHEMBL17317364 | 0.80 | MDM2 (0.67) | ALDH1A1MDM2STING1RAB9AHSD17B10 | |
| SCHEMBL29921322 | 0.80 | MDM2 (0.67) | ALDH1A1MDM2STING1RAB9AHSD17B10 | |
| SCHEMBL17317240 | 0.77 | ALDH1A1 (0.73) | ALDH1A1NPSR1SMN1; SMN2HTTSTING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163744-B2 | Tetrahydro-isoquinolin-1-ones for the treatment of cancer | NEXUSPHARMA, INC. (US) | 2012-04-24 | — | — | US | claimed |
| US-20090068144-A1 | TETRAHYDRO-ISOQUINOLIN-1-ONES FOR THE TREATMENT OF CANCER | NEXUSPHARMA INC. | 2009-03-12 | — | — | US | claimed |
| EP-4548977-A2 | NOVEL ISOQUINOLINES AS PROTEIN DEGRADERS, E7 DEGRADERS, ANTIVIRALS, TUMOR THERAPEUTICS AND IMMUNE SUPPRESSIVES | RDP Pharma AG (CH) | 2025-05-07 | — | — | EP | disclosed |
| US-20240208925-A1 | ISOQUINOLINE DERIVATIVES FOR USE AS ANTIVIRAL AND ANTITUMOUR AGENTS | PAGS CO., LTD. (KR) | 2024-06-27 | — | — | US | disclosed |
| CN-117377474-A | Isoquinoline derivatives as antiviral and antitumor agents | RDP制药股份公司 | 2024-01-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208925-A1 | ISOQUINOLINE DERIVATIVES FOR USE AS ANTIVIRAL AND ANTITUMOUR AGENTS | TP53, EIF2AK2, VHL | ALDH1A1 819/4885NPSR1 4480/4885SMN1; SMN2 3161/4885 |
| US-20090068144-A1 | TETRAHYDRO-ISOQUINOLIN-1-ONES FOR THE TREATMENT OF CANCER | ING2, HMGB2, NOTCH2 | ALDH1A1 1147/4885NPSR1 3985/4885SMN1; SMN2 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.