Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.43 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18469910 | 0.93 | ALDH1A1 (0.39) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL13196346 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL20987654 | 0.81 | ZDHHC20 (0.49) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL19176574 | 0.79 | ZDHHC20 (0.54) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL13196125 | 0.76 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL1104220 | 0.76 | ZDHHC20 (0.50) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL12128670 | 0.75 | KDM4E (0.36) | ALDH1A1TSHRMAPK1RIPK1 | |
| Alcohol SCHEMBL11584276 | 0.74 | TSHR (0.56) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| Propane SCHEMBL8855237 | 0.74 | TSHR (0.56) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 | |
| SCHEMBL20987657 | 0.73 | ALDH1A1 (0.41) | ALDH1A1TSHRMAPK1TDP1ZDHHC20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135835-A1 | MK2 INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135835-A1 | MK2 INHIBITORS AND USES THEREOF | MKNK2, DUSP2, MKNK1 | ALDH1A1 4078/4885TSHR 4677/4885MAPK1 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.