Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | MC5R | P33032 | 1/20 | 0.59 |
| ▸ | MC3R | P41968 | 1/20 | 0.59 |
| ▸ | MC1R | Q01726 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | G6PD | P11413 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11828168 | 0.87 | HTR2A (0.64) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL2732463 | 0.84 | HTR2A (0.69) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL30536673 | 0.84 | HTR2A (0.69) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL26688729 | 0.83 | HTR2A (0.67) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| Bromide SCHEMBL26186699 | 0.83 | HTR2A (0.67) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL21781048 | 0.82 | KDM4E (0.65) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL25076905 | 0.80 | HTR2C (0.68) | HTR2AHTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL1972829 | 0.80 | HTR2A (1.00) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL15130901 | 0.79 | KMT2A (0.74) | HTR2AHTR1AKDM4EALDH1A1HTT | |
| SCHEMBL13652758 | 0.79 | KDM4E (0.61) | HTR2AHTR1AKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | HTR2A 3593/4885HTR1A 4001/4885KDM4E 1641/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | HTR2A 3593/4885HTR1A 4001/4885KDM4E 1641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.