Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.42 |
| ▸ | NNMT | P40261 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674384 | 0.75 | KMT2A (0.41) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL171039 | 0.74 | KMT2A (0.53) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL4768283 | 0.73 | KMT2A (0.57) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL3163574 | 0.71 | KMT2A (0.55) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL1831265 | 0.71 | KMT2A (0.55) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL978974 | 0.71 | NNMT (0.63) | KMT2ASIRT6NNMTVNN1P4HA1 | |
| SCHEMBL4600085 | 0.71 | KMT2A (0.50) | KMT2ASIRT6NNMTVNN1P4HA1 | |
| SCHEMBL31654129 | 0.71 | KMT2A (0.55) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL157129 | 0.69 | KDM4E (0.67) | KMT2ASIRT6NNMTADORA3TSHR | |
| SCHEMBL3376769 | 0.69 | KMT2A (0.53) | KMT2ASIRT6NNMTADORA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957215-B2 | Heteroaryl substituted benzothiazoles | NAVIDEA BIOPHARMACEUTICALS, INC. (US) | 2015-02-17 | — | — | US | disclosed |
| US-20120207679-A1 | Novel Heteroaryl Substituted Benzothiazoles | ASTRAZENECA AB (SE) | 2012-08-16 | — | — | US | disclosed |
| US-8163928-B2 | Heteroaryl substituted benzothiazoles | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-20100092385-A1 | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| EP-2125800-A1 | NOVEL HETEROARYL SUBSTITUTED IMIDAZO Ý1,2 -A¨PYRIDINE DERIVATIVES | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| US-20090028787-A1 | Novel Heteroaryl Substituted Benzothiazoles | NAVIDEA BIOPHARMACEUTICALS, INC. | 2009-01-29 | — | — | US | disclosed |
| EP-1981883-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2008091195-A1 | NOVEL HETEROARYL SUBSTITUTED IMIDAZO [1,2 -A] PYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-07-31 | — | — | WO | disclosed |
| WO-2007086800-A1 | NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090028787-A1 | Novel Heteroaryl Substituted Benzothiazoles | APP, MAPT, PSEN1 | KMT2A 2021/4885SIRT6 3068/4885NNMT 1532/4885 |
| US-20100092385-A1 | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives | APP, PSEN1, PSEN2 | KMT2A 2816/4885SIRT6 2044/4885NNMT 779/4885 |
| US-20120207679-A1 | Novel Heteroaryl Substituted Benzothiazoles | MAPT, APP, PSEN1 | KMT2A 2764/4885SIRT6 2075/4885NNMT 1372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.