Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | PRF1 | P14222 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927582 | 0.90 | HIF1A (0.53) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL27961477 | 0.88 | KMT2A (0.51) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL30617944 | 0.88 | GSK3B (0.54) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL29186573 | 0.87 | GSK3B (0.52) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL28118461 | 0.87 | MKNK1 (0.54) | KMT2AGSK3BMKNK1MKNK2MAP4K4 | |
| SCHEMBL945743 | 0.87 | GSK3B (0.63) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL3347682 | 0.85 | KMT2A (0.49) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL28161825 | 0.85 | HRH3 (0.48) | KMT2AGSK3BMKNK1MKNK2PDE4A | |
| SCHEMBL4768271 | 0.85 | MKNK1 (0.65) | GSK3BMKNK1MKNK2SIRT6ADORA3 | |
| SCHEMBL31228498 | 0.85 | MKNK1 (0.65) | GSK3BMKNK1MKNK2SIRT6ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | KMT2A 99/4885GSK3B 701/4885MKNK1 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.