Ortetamine

Ortetamine

SCHEMBL209899

Cc1ccccc1C[C@@H](C)N

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.52
SLC6A2 P23975 3/20 0.52
SLC6A4 P31645 2/20 0.52
SLC6A3 Q01959 2/20 0.52
MAOA P21397 2/20 0.52
SIGMAR1 Q99720 1/20 0.52
CYP2A6 P11509 1/20 0.52
ADORA2A P29274 1/20 0.52
ADORA1 P30542 1/20 0.52
SOS2 Q07890 1/20 0.51
ADRB1 P08588 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA2A P08913 1/20 0.47
HTR1D P28221 1/20 0.47
HTR1B P28222 1/20 0.47
HTR2A P28223 1/20 0.47
HTR2C P28335 1/20 0.47
HTR1E P28566 1/20 0.47
HTR7 P34969 1/20 0.47
HTR2B P41595 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ortetamine SCHEMBL29388899 1.00 TAAR1 (0.52) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL27660676 1.00 TAAR1 (0.52) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL3460028 1.00 TAAR1 (0.52) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL42180 1.00 TAAR1 (0.52) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL16737004 0.98 TAAR1 (0.50) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL744048 0.98 TAAR1 (0.50) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL4381142 0.90 SLC6A4 (0.70) TAAR1SLC6A2SLC6A4SLC6A3MAOA
SCHEMBL2857779 0.85 SLC6A2 (0.61) TAAR1SLC6A2SLC6A4SLC6A3MAOA
Ortetamine SCHEMBL27703116 0.83 CYP2D6 (0.44) TAAR1SLC6A2SLC6A4SLC6A3MAOA
SCHEMBL727640 0.83 SOS2 (0.53) TAAR1SLC6A2SLC6A4SLC6A3MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260069546-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF VIVUS LLC (US) 2026-03-12 US disclosed
US-20240366513-A1 Methods For Administering Weight Loss Medications NALPROPION PHARMACEUTICALS LLC (US) 2024-11-07 US disclosed
US-12048769-B2 Methods for administering weight loss medications NALPROPION PHARMACEUTICALS LLC (US) 2024-07-30 US disclosed
US-20230301922-A1 Layered Pharmaceutical Formulations NALPROPION PHARMACEUTICALS LLC (US) 2023-09-28 US disclosed
US-20230225981-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF AMERICAN ENTERTAINMENT PROPERTIES CORP., AS LENDER 2023-07-20 US disclosed
US-20210378972-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF VIVUS LLC 2021-12-09 US disclosed
US-20200352863-A1 Methods For Administering Weight Loss Medications Naipropion Pharmaceuticals LLC (US) 2020-11-12 US disclosed
US-20200188313-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF VIVUS LLC (F/K/A VIVUS, INC.) 2020-06-18 US disclosed
US-20190350866-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF VIVUS, INC. 2019-11-21 US disclosed
US-20190282503-A1 Methods For Administering Weight Loss Medications WILMINGTON SAVINGS FUND SOCIETY, FSB 2019-09-19 US disclosed
US-20110059170-A1 METHODS FOR ADMINISTERING WEIGHT LOSS MEDICATIONS OREXIGEN THERAPEUTICS, INC. (US) 2011-03-10 US disclosed
US-20100215739-A1 LOW DOSE TOPIRAMATE / PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF VIVUS LLC (F/K/A VIVUS, INC.) 2010-08-26 US disclosed
EP-2089005-B1 LAYERED PHARMACEUTICAL FORMULATIONS COMPRISING AN INTERMEDIATE RAPIDLY DISSOLVING LAYER OREXIGEN THERAPEUTICS INC (US) 2010-03-17 EP disclosed
WO-2009152189-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSTION AND METHODS OF USE THEREOF VIVUS, INC. (US) 2009-12-17 WO disclosed
EP-2088998-A2 UNIT DOSAGE PACKAGE AND METHODS FOR ADMINISTERING WEIGHT LOSS MEDICATIONS Orexigen Therapeutics, Inc. (US) 2009-08-19 EP disclosed
EP-2089005-A2 LAYERED PHARMACEUTICAL FORMULATIONS COMPRISING AN INTERMEDIATE RAPIDLY DISSOLVING LAYER Orexigen Therapeutics, Inc. (US) 2009-08-19 EP disclosed
WO-2008060963-A2 LAYERED PHARMACEUTICAL FORMULATIONS COMPRISING AN INTERMEDIATE RAPIDLY DISSOLVING LAYER OREXIGEN THERAPEUTICS, INC. (US) 2008-05-22 WO disclosed
WO-2008060964-A2 UNIT DOSAGE PACKAGE AND METHODS FOR ADMINISTERING WEIGHT LOSS MEDICATIONS OREXIGEN THERAPEUTICS, INC. (US) 2008-05-22 WO disclosed
US-20080113026-A1 LAYERED PHARMACEUTICAL FORMULATIONS OREXIGEN THERAPEUTICS, INC (US) 2008-05-15 US disclosed
US-20080110792-A1 METHODS FOR ADMINISTERING WEIGHT LOSS MEDICATIONS OREXIGEN THERAPEUTICS, INC. (US) 2008-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210378972-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF HTR3A, TPH1, HTR1B TAAR1 117/4885SLC6A2 23/4885SLC6A4 32/4885
US-20100215739-A1 LOW DOSE TOPIRAMATE / PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF HTR3A, TPH1, HTR1B TAAR1 117/4885SLC6A2 23/4885SLC6A4 32/4885
US-20260069546-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF HTR1B, SLC6A2, HTR2B TAAR1 51/4885SLC6A2 2/4885SLC6A4 6/4885
US-20230225981-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF HTR3A, TPH1, HTR1B TAAR1 117/4885SLC6A2 23/4885SLC6A4 32/4885
US-20200188313-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF HTR3A, TPH1, HTR1B TAAR1 117/4885SLC6A2 23/4885SLC6A4 32/4885
US-20190350866-A1 LOW DOSE TOPIRAMATE/PHENTERMINE COMPOSITION AND METHODS OF USE THEREOF HTR3A, TPH1, HTR1B TAAR1 117/4885SLC6A2 23/4885SLC6A4 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.