Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 8/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20990414 | 1.00 | NQO2 (0.47) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL20990418 | 0.91 | CYP19A1 (0.42) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL20990419 | 0.91 | CYP19A1 (0.42) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL26974001 | 0.88 | CYP19A1 (0.35) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL26974000 | 0.88 | CYP19A1 (0.35) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL29410260 | 0.87 | NQO2 (0.49) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL20990004 | 0.87 | NQO2 (0.49) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL21959768 | 0.87 | NQO2 (0.49) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL20990008 | 0.87 | NQO2 (0.49) | NQO2CYP19A1IDO1TDO2CASP6 | |
| SCHEMBL20990126 | 0.87 | NQO2 (0.46) | NQO2CYP19A1IDO1TDO2CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858946-B2 | Small molecules active against gram-negative bacteria | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-01-02 | — | — | US | disclosed |
| US-10995097-B2 | Small molecules active against gram-negative bacteria | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-05-04 | — | — | US | disclosed |
| US-20190135821-A1 | SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10995097-B2 | Small molecules active against gram-negative bacteria | PGLS, MRPL21, CLPP | NQO2 192/4885CYP19A1 4569/4885IDO1 1470/4885 |
| US-11858946-B2 | Small molecules active against gram-negative bacteria | PGLS, MRPL21, CLPP | NQO2 246/4885CYP19A1 4689/4885IDO1 1733/4885 |
| US-20190135821-A1 | SMALL MOLECULES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | PGLS, MRPL21, CLPP | NQO2 192/4885CYP19A1 4569/4885IDO1 1470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.