Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.42 |
| ▸ | TNF | P01375 | 6/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.40 |
| ▸ | IL1B | P01584 | 3/20 | 0.40 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250730 | 0.80 | CRBN (0.64) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL18975947 | 0.79 | CRBN (0.53) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL24818018 | 0.79 | CRBN (0.48) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL19646674 | 0.79 | CRBN (0.42) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL21906782 | 0.79 | CRBN (0.46) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL22857769 | 0.78 | CRBN (0.46) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL21897792 | 0.78 | CRBN (0.46) | CRBNIKZF3DDB1 | |
| SCHEMBL20759933 | 0.78 | CRBN (0.45) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL19222352 | 0.78 | CRBN (0.66) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL19541974 | 0.77 | CRBN (0.49) | CRBNIKZF3TNFDDB1IL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669257-B2 | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORPORATION (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190135780-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10669257-B2 | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CYP3A7, CYP3A4, CYP3A43 | CRBN 2429/4885IKZF3 2341/4885TNF 4590/4885 |
| US-20190135780-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CYP3A7, CYP3A4, CYP3A43 | CRBN 2429/4885IKZF3 2341/4885TNF 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.