Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 3/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20993167 | 0.84 | RIPK1 (0.48) | RIPK1ALDH1A1MAPTNPEPPSGFER | |
| SCHEMBL24351537 | 0.83 | RIPK1 (0.40) | RIPK1ALDH1A1MAPTNPEPPSGFER | |
| SCHEMBL20993431 | 0.82 | RIPK1 (0.40) | RIPK1ALDH1A1MAPTIDH1SMN1; SMN2 | |
| SCHEMBL20993164 | 0.82 | RIPK1 (0.40) | RIPK1ALDH1A1MAPTIDH1NPEPPS | |
| SCHEMBL278629 | 0.80 | RIPK1 (0.45) | RIPK1ALDH1A1MAPTNPEPPSPRMT5 | |
| SCHEMBL20993169 | 0.80 | RIPK1 (0.45) | RIPK1ALDH1A1MAPTIDH1NPEPPS | |
| SCHEMBL20993571 | 0.78 | RIPK1 (0.43) | RIPK1ALDH1A1MAPTNPEPPSPRMT5 | |
| SCHEMBL20993163 | 0.78 | RIPK1 (0.43) | RIPK1ALDH1A1MAPTNPEPPSGFER | |
| SCHEMBL23153281 | 0.77 | RIPK1 (0.42) | RIPK1ALDH1A1MAPTIDH1NPEPPS | |
| SCHEMBL20993582 | 0.76 | HRH3 (0.42) | RIPK1ALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS INC (US) | 2022-04-21 | — | — | US | disclosed |
| US-11248000-B2 | Quinazoline and indole compounds to treat medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2022-02-15 | — | — | US | disclosed |
| US-10961252-B2 | Quinazoline and indole compounds to treat medical disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| US-20200165262-A1 | Quinazoline and Indole Compounds to Treat Medical Disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2020-05-28 | — | — | US | disclosed |
| US-20190135825-A1 | Quinazoline and Indole Compounds to Treat Medical Disorders | ACHILLION PHARMACEUTICALS, INC. (US) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11248000-B2 | Quinazoline and indole compounds to treat medical disorders | CFB, TFPI, MAOB | RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885 |
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | CFB, TFPI, MAOB | RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885 |
| US-10961252-B2 | Quinazoline and indole compounds to treat medical disorders | CFB, TFPI, MAOB | RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885 |
| US-20200165262-A1 | Quinazoline and Indole Compounds to Treat Medical Disorders | CFB, TFPI, MAOB | RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885 |
| US-20190135825-A1 | Quinazoline and Indole Compounds to Treat Medical Disorders | CFB, TFPI, MAOB | RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.