Sugi Predict

Sugi Predict / Compounds / SCHEMBL20993167

SCHEMBL20993167

SCHEMBL20993167

CC(C)(C)N1CC(c2ccccn2)N(C(C)(C)C)CC1c1ccccn1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 1/20 0.48
▸ ALDH1A1 P00352 4/20 0.41
▸ MAPT P10636 2/20 0.41
▸ NPEPPS P55786 2/20 0.39
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ CCR1 P32246 1/20 0.35
▸ CCR5 P51681 1/20 0.35
▸ CCR8 P51685 1/20 0.35
▸ METAP1 P53582 1/20 0.35
▸ BLM P54132 1/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ DOHH Q9BU89 1/20 0.35
▸ P4HTM Q9NXG6 1/20 0.35
▸ GFER P55789 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20993571 0.92 RIPK1 (0.43) RIPK1ALDH1A1MAPTNPEPPSNPC1
SCHEMBL20993163 0.92 RIPK1 (0.43) RIPK1ALDH1A1MAPTNPEPPSNPC1
SCHEMBL22024153 0.88 RIPK1 (0.40) RIPK1ALDH1A1MAPTNPEPPSKDM4E
SCHEMBL20993166 0.84 RIPK1 (0.42) RIPK1ALDH1A1MAPTNPEPPSNPC1
SCHEMBL22024157 0.83 RIPK1 (0.39) RIPK1ALDH1A1MAPTNPEPPS
SCHEMBL278629 0.81 RIPK1 (0.45) RIPK1ALDH1A1MAPTNPEPPSPRMT5
SCHEMBL24352594 0.81 RIPK1 (0.40) RIPK1ALDH1A1MAPTNPEPPSKMT2A
SCHEMBL20993431 0.81 RIPK1 (0.40) RIPK1ALDH1A1MAPTKMT2ACYP1A2
SCHEMBL20993164 0.81 RIPK1 (0.40) RIPK1ALDH1A1MAPTNPEPPSKMT2A
SCHEMBL20993169 0.78 RIPK1 (0.45) RIPK1ALDH1A1MAPTNPEPPSNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11248000-B2 Quinazoline and indole compounds to treat medical disorders ACHILLION PHARMACEUTICALS, INC. (US) 2022-02-15 — — US disclosed
US-10961252-B2 Quinazoline and indole compounds to treat medical disorders ACHILLION PHARMACEUTICALS, INC. (US) 2021-03-30 — — US disclosed
US-20200165262-A1 Quinazoline and Indole Compounds to Treat Medical Disorders ACHILLION PHARMACEUTICALS, INC. (US) 2020-05-28 — — US disclosed
US-20190135825-A1 Quinazoline and Indole Compounds to Treat Medical Disorders ACHILLION PHARMACEUTICALS, INC. (US) 2019-05-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11248000-B2 Quinazoline and indole compounds to treat medical disorders CFB, TFPI, MAOB RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885
US-10961252-B2 Quinazoline and indole compounds to treat medical disorders CFB, TFPI, MAOB RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885
US-20200165262-A1 Quinazoline and Indole Compounds to Treat Medical Disorders CFB, TFPI, MAOB RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885
US-20190135825-A1 Quinazoline and Indole Compounds to Treat Medical Disorders CFB, TFPI, MAOB RIPK1 3732/4885ALDH1A1 3311/4885MAPT 2374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.